Hepatoprotective and Nephroprotective Effects of Haronga (Harungana madagascariensis) in Combination with Antioxidant Compounds in Albino Spraque Dawley Rats

Aim: The aim of this study was to evaluate the effects Harungana madagascariensis stem bark ethyl acetate extract with antioxidants on liver and kidney in rats.
 Study Design: Experimental.
 Place Duration Study: Department Veterinary Pharmacology Toxicology, University Ibadan (from January-February, 2020).
 Methodology: This done using Albino rats (Wistar) grouped into 12 5 animals per group for protective studies,ethyl (EHM) plant at 100mg/kg, 200mg/kg 500mg/kg combination each Ascorbic acid (200mg/kg), Selenium (1mg/kg) and/or Allopurinol (50mg/kg). Group I-III are control groups, IV-VI EHM/Ascorbic acid, groups VII-IX EHM/Se, X-XII EHM/AL. were administered 8 days prior acetaminophen (800mg/kg) day 9. Animals sacrificed 10 samples collected biochemical histopathological evaluations.
 Results: showed that induced-stress causing increase biomarkers such as aspartate transaminase (AST), alanine (ALT), alkaline phosphate (ALP), creatinine, blood urea, total protein gamma-glutamyl transferase (GGT). H. madagasacariensis Ethyl different doses causes by reducing release stabilized elevated enzymes level shown group. histopathology moderate portal congestion mild periportal cellular infiltration a severe fibrosis, while diffuse tubular degeneration necrosis.
 Conclusion: EHM (500 mg/kg 200 mg/kg) or protected from injury induced Acetaminophen. synergy prevent both organs.